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New Research And A Pill To Prevent Phobias

Jun 08, 2016
by Caroline Miller
agoraphobia, anxiety, Ben Crair, Merel Klindt, panic attacts, PTSD, reconsolidation, The Cure For Fear
4 Comments

A friend of mine was driving along a freeway one  dark and stormy night when she was overcome by a fear that forced her off the highway.  Except for the pounding rain, nothing out of the ordinary had happened. Still she was so upset, she asked the friend with her  to drive them home. She’d suffered a panic attack, her first, triggered by an unknown event.  When she told me her story, I urged her to get counseling.  Panic attacks don’t usually go away by themselves.  Instead, they  grow into phobias that can take over a person’s life. The human response is to avoid the experience associated with the anxiety.  But, untreated, the  fear can grow and associate itself with other activities until staying at home can seem the only safe option, a condition known as agoraphobia.

Drugs exist to deal with phobias, though recently, Alzheimer’s research has brought some of them under suspicion.  Psychotherapy is another form of treatment. Unfortunately, years can pass before the reason for the attack is uncovered. Even then, knowing the reason doesn’t necessarily affect a cure.  

clown phobia

Courtesy of yahoo.com

Not surprising, some doctors have thrown out psychotherapy in favor of aversion therapy, which is quicker.  If someone is afraid of clowns, for example, the patient gets exposed to them in slow measures, over time. Unfortunately, facing one’s fear to cure that fear is difficult and not always effective, either. 

Merel Klindt, a professor of clinical psychology, working in her laboratory in Amsterdam, has created a pill, which taken once, may permanently eliminate an anxiety. “The Cure For Fear,” by Ben Crair, New Republic, June 2016, pgs. 30-37.)  Anxiety overwhelms us when too much adrenaline gets released as we form an unpleasant memory.(Ibid pg. 34)   Klindt’s pill, taken at the right moment, can reconfigure the response.  The right moment occurs during a period of “reconsolidation”: when an old memory is retrieved and a new one formed.  Klindt’s medication can interrupt the relived memory and replace it with one devoid of anxiety. (Ibid pg. 36)  

As good as that sounds, the treatment has its limits.  The effect isn’t transferable.  A person who dreads standing on high balconies can cure that specific fear, but he or she may retain a dread of other high places.  (Ibid pg 33)  Regrettably, people with PTSD aren’t as responsive to pharmacological rewriting as those with simple phobias.  Their  fear is too complex, though the treatment can offer some relief. (Ibid 34)

Fear, like pain, has a positive role to play in our lives.  But when our responses become too debilitating, Klindt’s pill may offer a life saving alternative.

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4 Comments
  1. John Briggs June 8, 2016 at 8:35 am Reply
    "It was a dark and stormy night." When we hear, read, or see that opening in a piece of fiction, we expect to be frightened. The question is when and how. Many of us keep going back to that beginning, keep entering the maze with monster at its core. Many (not all of us) find entertainment there. Many find something more, depending upon the quality of the literary experience and their own response to it. Those who don't enter seem to find mazes and monsters elsewhere, of different kinds. In any case, it is hard to imagine a literature without such tales. They do not comprise the world of literature, but without them one wonders how many works of great literature would be left: Homer, Ovid, Virgil, the Bible, Shakespeare, Romantic poetry, would be on a list of dangerous unpleasantries. Panic attacks are an experience of another order. They are disabling, and come at moments we least expect, often in circumstances that seem alien to the fear. We haven't chosen to enter a theater; the maze and monster come to us in guises of occasion and appearance we hardly expect. What someone might think is a heart attack is eventually revealed to be a combination of intense activity, sadness, regret, and unspoken horror on the occasion of emptying one's parents' home. The literary art cannot cure such attacks. It probably cannot prevent them. But in the less crisis-ridden periods of our lives it can be a release of such fears, and a deep strengthening of our powers of recovery and reflection. It's not for nothing that tragedy flourished in Periclean Athens and Elizabethan England, two triumphant eras of prosperity and high spirits. In those robust times, extraordinary literary tragedies emerged to a-maze and confront audiences with the fear and pathos of the human condition. If a literary art is capable of deeply moving those passions, it can stir powers of recovery that minister to our weaknesses and temper our strengths as human beings.
    • Caroline Miller June 8, 2016 at 8:49 am Reply
      I can add nothing but a thank you for your thought provoking reply.
  2. Pamela June 8, 2016 at 10:57 am Reply
    As someone who suffers from anxiety, I read your piece here with interest, Caroline. I just want to comment that there are usually multiple neurotransmitters involved in an anxious or panic episode, and often more than one trigger. Panic, in my case, seemed to arise from adrenal fatigue--a condition of sustained stress and can include a health component, as well as a predisposition (potentially genetic) component as well. I feel that therapy, diet, exercise, medication, supplements--all can alleviate the strength and number of panic attacks. Panic is a slippery devil, and, at least in my case, you might think you've located and teased out the trauma and treatment, only to have a new vicissitude of life release another trigger. :-(
    • Caroline Miller June 8, 2016 at 4:12 pm Reply
      Yes, I have heard that good or bad diets can alleviate or be a contributing factor. Thank you for expanding our understanding, Pamela.

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Contact Caroline at

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Portland, Oregon author Caroline Miller had distinguished careers as an educator, union president, elected official and artist/advocate.

Her play, Woman on the Scarlet Beast, was performed at the Post5 Theatre, Portland, OR, January/February 2015

Caroline published a serialized novelette, Marie Eau-Claire, on the website, The Colored Lens.  She also published the story Gustav Pavel,  a parable about ordinary lives, choice and alternate potential, on the website Fixional.co.

Caroline has published five novels

  • Getting Lost To Find Home
  • Ballet Noir
  • Trompe l’Oeil
  • Gothic Spring
  • Heart Land

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